Conditional Cell Penetration
RALA is a 30 amino acid peptide with the following advantages for precision drug delivery:
RALA nanoparticles have many advantages
High cell transfection / cellular entry without associated toxicity
Self-assembly with nucleic cargo, irrespective of size
Stable nanoparticle with no need for cold chain storage
Non-immunogenic nanoparticles facilitate repeated dosing
Protection of drug cargo while increasing circulatory half-life
Demonstrated formulation lyophilisation and easy scale up
RALA is optimised for both localised and systemic delivery, excelling in in vitro, in vivo and ex vivo applications.
RALA-V is an optimised RALA & triple-plasmid nanoparticle system for efficient and cost-effective production of AAV viral vectors for use in gene therapy applications
Over 20+ studies have been published using the RALA system, ranging from the fundamental design and application of an efficient cell penetrating peptide to use as a potential therapeutic mRNA vaccine candidate.
Below is a selection of publications of special note: